Directed Hydroformylation with Catalytic Amounts of Catalyst-Directing Groups
A drawback of the CDG concept is the requirement for stoichiometric amounts of the directing group. To achieve similar selectivity control with catalytic amounts of a CDG the concept of a covalent but reversibly bound directing group has been implemented recently.[106,121]
Schema 12: Concept of a covalent but reversibly bound Catalyst-Directing Group and its implementation in hydroformylation.
Thus, using a simple phosphinite as the reversible CDG a highly regio- and diastereoselective hydroformylation homo- and bishomoallylic alcohols could be achieved.[106,121]