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Target Oriented Synthesis in the Breit Group

 Target Oriented Synthesis in the Breit Group

Beside our group’s research affords in Catalysis we are also interested in general Organic Synthesis towards naturally occurring and/or biologically interesting molecules. In order to meet the above-mentioned criterias we attempt to apply our recently developed methodologies to provide a concise and efficient synthetic access to certain interesting natural products. A short summary of highlights is given below. 

 

 

Total Synthesis of (–)-Cylindrocyclophane F: A Yardstick for Probing New Catalytic C–C Bond-Forming Methodologies 

 

CylindrocyclophaneF

D. Berthold, B. Breit Chem. Eur. J. 201824, 16770–16773.

 

 

Total Synthesis of (18S) and (18R)Homolargazole by RhodiumCatalyzed Hydrocarboxylation

Homolargozole

C. Schotes, D. Ostrovskyi, J. Senger, K. Schmidtkunz, M. Jung, B. Breit Chem. Eur. J. 201420, 2164–2168.

 

Concise Total Syntesis of (−)-Vermiculine through a Rhodium-Catalyzed C2Symmetric Dimerization Strategy

Vermiculine

P. Steib, B. Breit Chem. Eur. J. 201925, 3532–3535.

 

Regio- and Enantioselective Synthesis of N-Substituted Pyrazoles by Rhodium-Catalyzed Asymmetric Addition to Allenes

Ruxolitinib

A. M. Haydl, K. Xu, B. Breit Angew. Chem. 2015127, 7017–7021; Angew. Chem. Int. Ed. 201554, 7149–7153.

 

For further, recent Highlights in Target Oriented Synthesis, see: 

 

 

[1] P. A. Spreider, B. Breit Org. Lett. 201820, 3286–3290. 

[2] Y. Zhou, B. Breit Chem Eur. J. 201723, 18156–18160. 

[3] A. Haydl, B. Breit Chem. Eur. J. 201723, 541–545.

[4] A. Haydl, D. Berthold, P. A. Spreider Angew. Chem. 2016128, 5859–5863; Angew. Chem. Int. Ed. 201655, 5765–5769.

[5] A. Haydl, B. Breit Angew. Chem. 2015127, 15750–15754; Angew. Chem. Int. Ed. 201554, 15530–15534.

[6] S. Wünsch, B. Breit Chem. Eur. J. 201521, 2358–2363.

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