Hot Paper Angewandte Chemie
Self-Assembled Bidentate Ligands for the Nickel-Catalyzed Hydrocyanation of Alkenes
Michiel de Greef, Dr., Bernhard Breit, Prof. Dr. *
Well-stocked library: A catalyst with interesting activity, regioselectivity (rs), and functional-group tolerance could be identified from a 5 x 4 library of isoquinolone- or aminopyridine-derived self-assembled bidentate ligands. These ligands, which self-assemble through hydrogen bonding, form complexes with nickel(0) that appeared to be promising catalysts for the hydrocyanation of styrene (see scheme).
DOI=10.1002/anie.200805092