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Catalytic Domino Processes

 

    Merging skeleton expanding operations as Domino type processes can provide a rapid increase of molecular complexity. Particularly attractive is the incorporation of catalytic steps. Examples from our laboratories are the first hydroformylation/Wittig-olefination/hydrogenation[33,60] (equation 1) and hydroformylation-Knoevenagel-hydrogenation reactions[41] (equation 2) which allow for the efficient construction of polyketide structural elements with high levels of acyclic stereocontrol (Scheme 11).

Scheme 11: Catalytic Domino reactions employing alkene hydroformylation.

 Scheme11ns.png

 

Furthermore, a Domino hydroformylation/organocatalytic cross aldol reaction was developed which starting from simple alkene feedstocks and synthesis gas provides polypropionate building blocks in excellent levels of enantioselectivity (equation 3).[85]

 

 

 

 
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